ARA-290 (Cibinetide)
Tissue Protection • Neurobiology • Innate Repair Receptor Research
For Research Use Only
Overview
ARA-290, also known as Cibinetide, is a synthetic 11-amino-acid peptide modeled after the helix-B region of erythropoietin (EPO).
Researchers developed ARA-290 to investigate EPO-associated tissue-protective and repair signaling while avoiding activation of the classical EPO pathway responsible for increased red blood cell production.
ARA-290 has been investigated in both preclinical models and early human clinical research involving nerve biology, inflammatory signaling, tissue injury, metabolic physiology, and small-fiber neuropathy.
Research Areas
ARA-290 has been investigated in research involving:
- Peripheral nerve biology
- Small-fiber nerve research
- Neuroinflammatory signaling
- Tissue-protection pathways
- Cellular repair mechanisms
- Neuropathic pain models
- Inflammatory responses
- Metabolic physiology
- Ischemia/reperfusion models
- Neural regeneration
- Cellular stress responses
- Tissue recovery
Unlike many experimental peptides, ARA-290 has progressed beyond animal models into human clinical studies, although it remains investigational.
Mechanism Being Studied
Researchers primarily investigate ARA-290 for its interaction with the Innate Repair Receptor (IRR), described as a receptor complex involving the erythropoietin receptor (EPOR) and the β-common receptor/CD131.
Activation of this pathway has been investigated in relation to:
- Anti-inflammatory signaling
- Cellular survival pathways
- Reduced apoptotic signaling
- Tissue-protective responses
- Neural repair
- Neurite growth
- Cellular responses following injury
Importantly, ARA-290 was engineered to investigate these pathways without producing the erythropoietic activity associated with conventional EPO signaling.
Why Researchers Study ARA-290
ARA-290 is particularly interesting because it allows researchers to separate two very different aspects of erythropoietin biology:
EPO → Red Blood Cell Production
versus
ARA-290 → Tissue-Protective / Innate Repair Signaling
This distinction has led researchers to investigate ARA-290 in models involving:
- Peripheral nerve injury
- Neuroinflammation
- Tissue repair
- Cellular stress
- Ischemic injury
- Metabolic dysfunction
- Small-fiber nerve pathology
A Phase 2 study in people with type 2 diabetes and painful neuropathy reported changes in neuropathic symptoms, metabolic measures, and corneal nerve-fiber density, but these findings do not establish ARA-290 as an approved treatment.
Product Features
✔ Premium Research Grade
✔ High-Purity ARA-290 / Cibinetide
✔ Third-Party Tested (COA Available)
✔ Identity & Purity Verification
✔ Secure Professional Packaging
✔ Laboratory Research Only
Common Research Applications
Researchers have explored ARA-290 in studies involving:
- Neurobiology
- Peripheral nerve physiology
- Small-fiber nerve research
- Innate Repair Receptor signaling
- Neuroinflammatory pathways
- Cellular survival
- Tissue-protection models
- Metabolic research
- Ischemia/reperfusion biology
- Regenerative signaling
Storage
Store according to the product’s batch-specific stability documentation. Protect lyophilized material from excessive heat, moisture, and direct sunlight.
Following preparation for laboratory experiments, use validated laboratory storage procedures and minimize unnecessary temperature cycling.
Disclaimer
For Research Use Only.
This product is intended exclusively for laboratory research and analytical purposes.
ARA-290/Cibinetide remains an investigational compound and is not an FDA-approved therapeutic product.
Not intended for human or veterinary use.
Why Choose Voltis Research Co.
At Voltis Research Co., quality begins with verification. Researchers deserve confidence that the compound identified on every vial accurately represents the material being investigated.
Qualifying batches undergo independent third-party analytical testing, with batch-specific Certificates of Analysis available to document identity and purity.
The Voltis Commitment
⚡ Research-Grade Quality
⚡ Independent Third-Party Testing
⚡ Batch-Specific Certificate of Analysis (COA)
⚡ High-Purity Research Peptides
⚡ Rigorous Quality Control
⚡ Secure Professional Packaging
⚡ Transparency, Consistency & Reliability
Powering Discovery Through Quality Research.
Ara-290 (16 mg Vial) Dosage Protocol
